Serial Quantification of Targeted Fumagillin Therapy Using a v b 3 - Targeted Paramagnetic Nanoparticles in Early Atherosclerosis at 1 . 5 T
نویسندگان
چکیده
Patrick M. Winter, PhD, Anne M. Morawski, BS, Shelton D. Caruthers, PhD, Thomas D. Harris, PhD, Grace Hu, PhD, Ralph W. Fuhrhop, Huiying Zhang, MD, John S. Allen, BS, Elizabeth K. Lacy, BS, Todd A. Williams, BS, Samuel A. Wickline, MD, Gregory M. Lanza, MD, PhD. Cardiology, Washington University, St. Louis, MO, USA, Philips Medical Systems, Cleveland, OH, USA, BristolMyers Squibb Medical Imaging, Billerica, MA, USA.
منابع مشابه
Endothelial 3 Integrin–Targeted Fumagillin Nanoparticles Inhibit Angiogenesis in Atherosclerosis
Objective—Angiogenic expansion of the vasa vasorum is a well-known feature of progressive atherosclerosis, suggesting that antiangiogenic therapies may stabilize or regress plaques. 3 Integrin–targeted paramagnetic nanoparticles were prepared for noninvasive assessment of angiogenesis in early atherosclerosis, for site-specific delivery of antiangiogenic drug, and for quantitative follow-up of ...
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